Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Kasus Nissim T
PROVIDER: S-EPMC5350565 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Ben-Kasus Nissim Tsipi T Zhang Xuexin X Elazar Assaf A Roy Soumitra S Stolwijk Judith A JA Zhou Yandong Y Motiani Rajender K RK Gueguinou Maxime M Hempel Nadine N Hershfinkel Michal M Gill Donald L DL Trebak Mohamed M Sekler Israel I
The EMBO journal 20170220 6
Mitochondria exert important control over plasma membrane (PM) Orai1 channels mediating store-operated Ca<sup>2+</sup> entry (SOCE). Although the sensing of endoplasmic reticulum (ER) Ca<sup>2+</sup> stores by STIM proteins and coupling to Orai1 channels is well understood, how mitochondria communicate with Orai1 channels to regulate SOCE activation remains elusive. Here, we reveal that SOCE is accompanied by a rise in cytosolic Na<sup>+</sup> that is critical in activating the mitochondrial Na< ...[more]