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A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment.


ABSTRACT: BACKGROUND:The connection between Alzheimer's disease (AD) and olfactory deficits is well documented and further, alterations in olfactory functioning may signal declines in functions associated with dementia. The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI). METHODS:Articles were identified through computerised literature search from inception to 30 June 2016 using PubMed, MEDLINE and PsychInfo databases. In order to control for differences in sample size during effect size computation, studies were weighted according to their inverse variance estimates. RESULTS:31 articles (62 effects) were identified, which included 1993 MCI patients and 2861 healthy older adults (HOA). Included studies contrasted odour identification, discrimination, detection threshold and/or memory between cases and controls. Moderate to large and heterogeneous effects were seen for olfactory deficits in MCI relative to HOA (d=-0.76, 95% CI -0.87

SUBMITTER: Roalf DR 

PROVIDER: S-EPMC5350628 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment.

Roalf David R DR   Moberg Madelyn J MJ   Turetsky Bruce I BI   Brennan Laura L   Kabadi Sushila S   Wolk David A DA   Moberg Paul J PJ  

Journal of neurology, neurosurgery, and psychiatry 20161230 3


<h4>Background</h4>The connection between Alzheimer's disease (AD) and olfactory deficits is well documented and further, alterations in olfactory functioning may signal declines in functions associated with dementia. The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI).<h4>Methods</h4>Articles were identified through computerised literature search from inception to 30 June 2016 using PubMed, MEDLINE and PsychIn  ...[more]

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