Genotyping HLA-B*5801 for Allopurinol-Induced Severe Cutaneous Adverse Reactions: An Accurate and Prompt Method.
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ABSTRACT:
SUBMITTER: Cheng L
PROVIDER: S-EPMC5351112 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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Genotyping HLA-B*5801 for Allopurinol-Induced Severe Cutaneous Adverse Reactions: An Accurate and Prompt Method.
Cheng Lin L Zhang Lihua L Gao Lichen L Zhang Wei W Chen Xiaoping X Zhou Hong-Hao HH
Clinical and translational science 20151214 6
<h4>Objectives</h4>A new method of HLA-B*5801 genotyping was compared with sequence-based typing (SBT) to find an accurate and prompt method in genotyping HLA-B*5801.<h4>Methods</h4>Two groups of patients from allopurinol-induced cutaneous adverse reactions (SCARs) and allopurinol-tolerant were both genotyped with PG5801 kit and SBT method. The genotyping results of HLA-B*5801 were compared between the two groups.<h4>Results</h4>The PG5801 detection kit results were 100% (79/79) in agreement wit ...[more]
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