Ontology highlight
ABSTRACT:
SUBMITTER: Hung SI
PROVIDER: S-EPMC554812 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Hung Shuen-Iu SI Chung Wen-Hung WH Liou Lieh-Bang LB Chu Chen-Chung CC Lin Marie M Huang Hsien-Ping HP Lin Yen-Ling YL Lan Joung-Liang JL Yang Li-Cheng LC Hong Hong-Shang HS Chen Ming-Jing MJ Lai Ping-Chin PC Wu Mai-Szu MS Chu Chia-Yu CY Wang Kuo-Hsien KH Chen Chien-Hsiun CH Fann Cathy S J CS Wu Jer-Yuarn JY Chen Yuan-Tsong YT
Proceedings of the National Academy of Sciences of the United States of America 20050302 11
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol-SCAR, we carried out a case-control association study. We enrolled 51 patients with allopurinol-SCAR and 228 control individ ...[more]