Dataset Information

In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG.

ABSTRACT:

Aim

This study reports structural modeling, molecular dynamics profiling of hypothetical proteins in Chlamydia abortus genome database.

Methodology

The hypothetical protein sequences were extracted from C. abortus LLG Genome Database for functional elucidation using in silico methods.

Results

Fifty-one proteins with their roles in defense, binding and transporting other biomolecules were unraveled. Forty-five proteins were found to be nonhomologous to proteins present in hosts infected by C. abortus. Of these, 31 proteins were related to virulence. The structural modeling of two proteins, first, WP_006344020.1 (phosphorylase) and second, WP_006344325.1 (chlamydial protease/proteasome-like activity factor) were accomplished. The conserved active sites necessary for the catalytic function were analyzed.

Conclusion

The finally concluded proteins are envisioned as possible targets for developing drugs to curtail chlamydial infections, however, and should be validated by molecular biological methods.

SUBMITTER: Singh G

PROVIDER: S-EPMC5351547 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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<i>In silico</i> functional elucidation of uncharacterized proteins of <i>Chlamydia abortus</i> strain LLG.

Singh Gagandeep G Sharma Dixit D Singh Vikram V Rani Jyoti J Marotta Francessco F Kumar Manoj M Mal Gorakh G Singh Birbal B

Future science OA 20170124 1

<h4>Aim</h4>This study reports structural modeling, molecular dynamics profiling of hypothetical proteins in <i>Chlamydia abortus</i> genome database.<h4>Methodology</h4>The hypothetical protein sequences were extracted from <i>C. abortus</i> LLG Genome Database for functional elucidation using <i>in silico</i> methods.<h4>Results</h4>Fifty-one proteins with their roles in defense, binding and transporting other biomolecules were unraveled. Forty-five proteins were found to be nonhomologous to p ...[more]

PMID: 28344832

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