Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside.
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ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC5351700 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside.
Wu Jingjing J Zhang Mingzhi M Liu Delong D
Oncotarget 20170101 4
The Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has been approved for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's macroglobulinemia. Acquired resistance to ibrutinib due to BTK C481S mutation has been reported. Mutations in PLCγ2 can also mediate resistance to ibrutinib. Untoward effects due to off-target effects are also disadvantages of ibrutinib. More selective and potent BTK inhibitors (ACP-196, ONO/GS-4059, BGB-3111, CC-292) are being invest ...[more]
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