Ontology highlight
ABSTRACT:
SUBMITTER: Mattison SA
PROVIDER: S-EPMC5352595 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell stress & chaperones 20161216 2
The Hsp70/Hsp90 organising protein (HOP) is a co-chaperone essential for client protein transfer from Hsp70 to Hsp90 within the Hsp90 chaperone machine. Although HOP is upregulated in various cancers, there is limited information from in vitro studies on how HOP expression is regulated in cancer. The main objective of this study was to identify the HOP promoter and investigate its activity in cancerous cells. Bioinformatic analysis of the -2500 to +16 bp region of the HOP gene identified a large ...[more]