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Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala.

ABSTRACT: Chromatographic isolation of the 80% MeOH extract of Acer ginnala (AG) yielded seven galloyl derivatives: gallic acid (1), ginnalin B (2), acertannin (3), maplexin D (4), maplexin E (5), quercetin-3-O-(2''-galloyl)-?-L-rhamnopyranoside (6), and kaempferol-3-O-(2''-galloyl)-?-L-rhamnopyranoside (7). This is the first study to report the isolation of compounds 4 and 5 from AG. Galloyl derivatives 3-7 exhibited potent radical scavenging activities, with 5 and 7 showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.7 cells. In addition, oral administration of AG extract (500?mg/kg?b.w.) improved symptoms of hyperglycemia and blunted the increases in serum GOT/GPT levels in a rat model of streptozotocin-induced diabetes. These results suggest that galloyl derivatives (1-7) are antioxidant and anti-inflammatory agents and that AG extract has potential as a functional material or novel herbal medicine for treating diabetes mellitus.

SUBMITTER: Park KH 

PROVIDER: S-EPMC5352893 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of <i>Acer ginnala</i>.

Park Kwan Hee KH   Yoon Kyu Hyeong KH   Yin Jun J   Le Thi Tam TT   Ahn Hye Sin HS   Yoon Seong Hye SH   Lee Min Won MW  

Evidence-based complementary and alternative medicine : eCAM 20170302

Chromatographic isolation of the 80% MeOH extract of <i>Acer ginnala</i> (AG) yielded seven galloyl derivatives: gallic acid (<b>1</b>), ginnalin B (<b>2</b>), acertannin (<b>3</b>), maplexin D (<b>4</b>), maplexin E (<b>5</b>), quercetin-3-<i>O</i>-(2''-galloyl)-<i>α</i>-L-rhamnopyranoside (<b>6</b>), and kaempferol-3-<i>O</i>-(2''-galloyl)-<i>α</i>-L-rhamnopyranoside (<b>7</b>). This is the first study to report the isolation of compounds <b>4</b> and <b>5</b> from AG. Galloyl derivatives <b>3  ...[more]

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