Ontology highlight
ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC5353601 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zhu Mu M Liu Jiafan J Xiao Jia J Yang Li L Cai Mingxiang M Shen Hongyu H Chen Xiaojia X Ma Yi Y Hu Sumin S Wang Zuolin Z Hong An A Li Yingxian Y Sun Yao Y Wang Xiaogang X
Nature communications 20170310
Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of myogenesis and adult skeletal muscle regeneration. However, the specific roles of lncRNAs in myogenic differentiation of adult skeletal muscle stem cells and myogenesis are still largely unknown. Here we identify a lncRNA that is specifically enriched in skeletal muscle (myogenesis-associated lncRNA, in short, lnc-mg). In mice, conditional knockout of lnc-mg in skeletal muscle results in muscle a ...[more]