Ontology highlight
ABSTRACT:
SUBMITTER: Qiao Y
PROVIDER: S-EPMC8211561 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Qiao Yina Y Jin Ting T Guan Shengdong S Cheng Shaojie S Wen Siyang S Zeng Huan H Zhao Maojia M Yang Liping L Wan Xueying X Qiu Yuxiang Y Li Qiao Q Liu Manran M Hou Yixuan Y
Oncogene 20210602 24
Invasion and metastasis are the leading causes of death in patients with breast cancer (BC), and epithelial-mesenchymal transformation (EMT) plays an essential role in this process. Here, we found that Lnc-408, a novel long noncoding RNA (lncRNA), is significantly upregulated in BC cells undergoing EMT and in BC tumor with lymphatic metastases compared with those without lymphatic metastases. Lnc-408 can enhance BC invasion and metastasis by regulating the expression of LIMK1. Mechanistically, L ...[more]