Ontology highlight
ABSTRACT:
SUBMITTER: Campillo N
PROVIDER: S-EPMC5353645 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Campillo Noelia N Torres Marta M Vilaseca Antoni A Nonaka Paula Naomi PN Gozal David D Roca-Ferrer Jordi J Picado César C Montserrat Josep Maria JM Farré Ramon R Navajas Daniel D Almendros Isaac I
Scientific reports 20170316
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE<sub>2</sub>). The contribution of the COX-2 in IH-induced ...[more]