Ontology highlight
ABSTRACT:
SUBMITTER: Vilaseca A
PROVIDER: S-EPMC5464763 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Vilaseca Antoni A Campillo Noelia N Torres Marta M Musquera Mireia M Gozal David D Montserrat Josep M JM Alcaraz Antonio A Touijer Karim A KA Farré Ramon R Almendros Isaac I
PloS one 20170608 6
We investigate the effects of intermittent hypoxia (IH), a characteristic feature of obstructive sleep apnea (OSA), on renal cancer progression in an animal and cell model. An in vivo mouse model (Balb/c, n = 50) of kidney cancer was used to assess the effect of IH on tumor growth, metastatic capacity, angiogenesis and tumor immune response. An in vitro model tested the effect of IH on RENCA cells, macrophages and endothelial cells. Tumor growth, metastatic capacity, circulating vascular endothe ...[more]