Ontology highlight
ABSTRACT:
SUBMITTER: Jongbloets BC
PROVIDER: S-EPMC5353663 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Jongbloets Bart C BC Lemstra Suzanne S Schellino Roberta R Broekhoven Mark H MH Parkash Jyoti J Hellemons Anita J C G M AJ Mao Tianyi T Giacobini Paolo P van Praag Henriette H De Marchis Silvia S Ramakers Geert M J GM Pasterkamp R Jeroen RJ
Nature communications 20170310
The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively ...[more]