Dataset Information

Applicability of ^99m Tc-Labeled Human Serum Albumin Scintigraphy in Dogs With Protein-Losing Enteropathy.

ABSTRACT:

Background

Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein-losing enteropathy (PLE), but it also allows for localization of protein loss.

Hypothesis/objectives

To investigate the feasibility of ^99m Tc-labeled human serum albumin (HSA) scintigraphy in dogs with PLE in comparison with control dogs.

Animals

A total of 8 clinically healthy control research dogs and 7 client-owned dogs with gastrointestinal clinical signs and hypoalbuminemia (serum albumin concentration <2.0 g/dL).

Methods

Prospective case-control study. After IV injection of 400 MBq freshly prepared ^99m Tc HSA (30 mg/dog), images of the abdomen were obtained 10, 60, 120, and 240 minutes postinjection. Additional images of the salivary and thyroid glands were obtained to rule out free ^99m Tc. A scan was considered positive for PLE when radiopharmaceutical exudation was detectable in the intestinal tract.

Results

Only 1 control dog showed exudation of the radiopharmaceutical into the intestinal tract. No free ^99m Tc was detected in any dog. In dogs with PLE, focal small intestinal and diffuse small intestinal radiopharmaceutical exudation into the bowel was detected in 2 and 3 dogs, respectively, whereas in 2 dogs, there was disagreement about whether radiopharmaceutical exudation was focal or diffuse.

Conclusion and clinical importance

^99m Tc-labeled HSA scintigraphy was feasible to diagnose PLE in dogs.

SUBMITTER: Engelmann N

PROVIDER: S-EPMC5354035 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Publications

Applicability of <sup>99m</sup> Tc-Labeled Human Serum Albumin Scintigraphy in Dogs With Protein-Losing Enteropathy.

Engelmann N N Ondreka N N von Pückler K K Mohrs S S Sicken J J Neiger R R

Journal of veterinary internal medicine 20170221 2

<h4>Background</h4>Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein-losing enteropathy (PLE), but it also allows for localization of protein loss.<h4>Hypothesis/objectives</h4>To investigate the feasibility of <sup>99m</sup> Tc-labeled human serum albumin (HSA) scintigraphy in dogs with PLE in comparison with control dogs.<h4>Animals</h4>A total of 8 clinically healthy co ...[more]

PMID: 28220598

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