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Palladium-catalysed synthesis of triaryl(heteroaryl)methanes.

ABSTRACT: Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C-C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and represents the first step towards a general transition metal catalysed synthesis of tetraarylmethanes.

SUBMITTER: Zhang S

PROVIDER: S-EPMC5355892 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Palladium-catalysed synthesis of triaryl(heteroaryl)methanes.

Zhang Shuguang S Kim Byeong-Seon BS Wu Chen C Mao Jianyou J Walsh Patrick J PJ

Nature communications 20170314

Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C-C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and represents the first step towards a general trans ...[more]

PMID: 28290445

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