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Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides.

ABSTRACT: A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit.

SUBMITTER: Lu C

PROVIDER: S-EPMC5603793 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides.

Lu Changhui C Gu Yang Y Wu Jiang J Gu Yucheng Y Shen Qilong Q

Chemical science 20170424 7

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. ...[more]

PMID: 28959407

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