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Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

ABSTRACT: mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls). We found that a total of 12 significant SNPs with false discovery rate (FDR) ?0.05 were mapped to one novel gene PRPF6 and two previously reported genes (DHX16 and LSM2) that were also confirmed in this study. The six novel SNPs in PRPF6 were in high linkage disequilibrium and associated with PRPF6 mRNA expression in lymphoblastoid cells from 373 Europeans in the 1000 Genomes Project. Taken together, our studies shed new light on the role of mRNA splicing genes in the development of lung cancer.

SUBMITTER: Pan Y

PROVIDER: S-EPMC5356340 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

Pan Yongchu Y Liu Hongliang H Wang Yanru Y Kang Xiaozheng X Liu Zhensheng Z Owzar Kouros K Han Younghun Y Su Li L Wei Yongyue Y Hung Rayjean J RJ Brhane Yonathan Y McLaughlin John J Brennan Paul P Bickeböller Heike H Rosenberger Albert A Houlston Richard S RS Caporaso Neil N Teresa Landi Maria M Heinrich Joachim J Risch Angela A Wu Xifeng X Ye Yuanqing Y Christiani David C DC Amos Christopher I CI Wei Qingyi Q

Scientific reports 20170317

mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard ...[more]

PMID: 28304396

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Dataset Information

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

Publications

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

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