Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC5356560 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kim Seok Jin SJ Shin Hyun-Tae HT Lee Hae-Ock HO Kim Nayoung K D NK Yun Jae Won JW Hwang Jee Hyang JH Kim Kihyun K Park Woong-Yang WY
Oncotarget 20161001 42
Clinically applicable platforms revealing actionable genomic alterations may improve the treatment efficacy of myeloma patients. In this pilot study, we used a high depth targeted sequencing panel containing 83 anti-cancer drug target genes to sequence genomic DNAs extracted from bone marrow aspirates of 23 patients with myeloma and 12 patients with amyloid light-chain (AL) amyloidosis. Mutation analysis revealed NRAS as the most commonly mutated gene (30%, 7/23) in myeloma patients followed by ...[more]