Ontology highlight
ABSTRACT:
SUBMITTER: Lou X
PROVIDER: S-EPMC5356675 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lou Xiaoli X Sun Bin B Song Jianxing J Wang Yicun Y Jiang Junhao J Xu Yang Y Ren Zeqiang Z Su Changqing C
Oncotarget 20161201 51
Human sulfatase 1 (hSulf-1) has aryl sulfatase activity. It can reduce the sulfation of cell surface heparan sulfate proteoglycan (HSPG) and inhibit various growth factor receptor-mediated signaling pathways. In most cancers, hSulf-1 is inactivated, which endows cancer cells with increasesed cell proliferation and metastatic activities, inhibition of apoptosis, and decreased sensitivity to radio- and chemotherapy. In this study, we found that hSulf-1 overexpression in melanoma cells can inhibit ...[more]