Ontology highlight
ABSTRACT:
SUBMITTER: Liu YX
PROVIDER: S-EPMC7039043 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Liu Yu-Xi YX Xu Bo-Wen BW Chen Ying-Jie YJ Fu Xiu-Qiong XQ Zhu Pei-Li PL Bai Jing-Xuan JX Chou Ji-Yao JY Yin Cheng-Le CL Li Jun-Kui JK Wang Ya-Ping YP Wu Jia-Ying JY Wu Ying Y Chan Kam-Kwan KK Liang Chun C Yu Zhi-Ling ZL
Oncology letters 20200117 3
Late stage melanoma is associated with a high mortality rate. Signal transducer and activator of transcription 3 (STAT3) is currently a target for melanoma treatment as it is constitutively activated with high frequency in melanoma. Dioscin is a natural steroid saponin that is present in several medical herbs. A previous study demonstrated that dioscin inhibits STAT3 signaling in a cerebral ischemia-reperfusion injury rat model. Furthermore, dioscin has been reported to exert anti-melanoma effec ...[more]