Ontology highlight
ABSTRACT:
SUBMITTER: Xue X
PROVIDER: S-EPMC5356677 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Xue Xinying X Liu Yuxia Y Wang Yong Y Meng Mingming M Wang Kaifei K Zang Xuefeng X Zhao Sheng S Sun Xiaohua X Cui Lei L Pan Lei L Liu Sanhong S
Oncotarget 20161201 51
Lung cancer remains the leading cause of cancer-associated death worldwide. MiR-21 and miR-155 are the most amplified miRNAs in non-small cell lung carcinoma (NSCLC), and are critical promoters of NSCLC progression. However, it remains unclear how miR-21 and miR-155 induce cancer progression, and whether these miRNAs share common targets, such as tumor suppressor genes required to prevent NSCLC. Here we report that miR-21 and miR-155 levels are elevated in NSCLC and are proportional to the progr ...[more]