Functional clues for hypothetical proteins based on genomic context analysis in prokaryotes.
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ABSTRACT:
SUBMITTER: Doerks T
PROVIDER: S-EPMC535681 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
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Functional clues for hypothetical proteins based on genomic context analysis in prokaryotes.
Doerks Tobias T von Mering Christian C Bork Peer P
Nucleic acids research 20041201 21
Three integrated genomic context methods were used to annotate uncharacterized proteins in 102 bacterial genomes. Of 7853 orthologous groups with unknown function containing 45,110 proteins, 1738 groups could be linked to functionally associated partners. In many cases, those partners are uncharacterized themselves (hinting at newly identified modules) or have been described in general terms only. However, we were able to assign pathways, cellular processes or physical complexes for 273 groups ( ...[more]
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