Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC5356929 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lee Melissa M Sanford Melanie S MS
Organic letters 20170117 3
This letter describes the development of a method for selective remote C(sp<sup>3</sup>)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp<sup>3</sup>)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is ap ...[more]