Ontology highlight
ABSTRACT:
SUBMITTER: Grasso S
PROVIDER: S-EPMC5357316 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170316
The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tum ...[more]