Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening.
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ABSTRACT:
SUBMITTER: Min Q
PROVIDER: S-EPMC5357792 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening.
Min Qiuxia Q Cai Xinpei X Sun Weiguang W Gao Fei F Li Zhimei Z Zhang Qian Q Wan Luo-Sheng LS Li Hua H Chen Jiachun J
Scientific reports 20170320
The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antihyperglycemic activity in db/db mice without obvious side effects such as excessive hypoglycaemia. ...[more]
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