Ontology highlight
ABSTRACT:
SUBMITTER: Posey AD
PROVIDER: S-EPMC5358667 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Posey Avery D AD Schwab Robert D RD Boesteanu Alina C AC Steentoft Catharina C Mandel Ulla U Engels Boris B Stone Jennifer D JD Madsen Thomas D TD Schreiber Karin K Haines Kathleen M KM Cogdill Alexandria P AP Chen Taylor J TJ Song Decheng D Scholler John J Kranz David M DM Feldman Michael D MD Young Regina R Keith Brian B Schreiber Hans H Clausen Henrik H Johnson Laura A LA June Carl H CH
Immunity 20160601 6
Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate robust responses against lineage restricted, non-essential targets in hematologic cancers. However, in solid tumors, the full potential of CAR T cell therapy is limited by the availability of cell surface antigens with sufficient cancer-specific expression. The majority of CAR targets have been normal self-antigens on dispensable hematopoietic tissues or overexpressed shared antigens. Here, we established that ...[more]