The role of feature curvature in contact guidance.
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ABSTRACT:
SUBMITTER: Mathur A
PROVIDER: S-EPMC5358675 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
The role of feature curvature in contact guidance.
Mathur Anurag A Moore Simon W SW Sheetz Michael P MP Hone James J
Acta biomaterialia 20120316 7
This study examines the role of feature curvature in cellular topography sensing. To separate the effects of feature size and curvature we have developed a method to fabricate grooved substrates whose radius of curvature (r) varies from under 10nm to 400 nm, while all other dimensions are kept constant. With increasing r up to 200 nm mouse embryonic fibroblasts increased their spread area, but reduced their polarization (aspect ratio). Interestingly, on features with r ≈ 200 and 400 nm, which ha ...[more]
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