Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC5358721 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Huang Chengyang C Su Trent T Xue Yong Y Cheng Chen C Lay Fides D FD McKee Robin A RA Li Meiyang M Vashisht Ajay A Wohlschlegel James J Novitch Bennett G BG Plath Kathrin K Kurdistani Siavash K SK Carey Michael M Carey Michael M
Genes & development 20170201 3
Chromobox homolog 3 (Cbx3/heterochromatin protein 1γ [HP1γ]) stimulates cell differentiation, but its mechanism is unknown. We found that Cbx3 binds to gene promoters upon differentiation of murine embryonic stem cells (ESCs) to neural progenitor cells (NPCs) and recruits the Mediator subunit Med26. RNAi knockdown of either Cbx3 or Med26 inhibits neural differentiation while up-regulating genes involved in mesodermal lineage decisions. Thus, Cbx3 and Med26 together ensure the fidelity of lineage ...[more]