Ontology highlight
ABSTRACT:
SUBMITTER: Turtle JD
PROVIDER: S-EPMC5359686 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Turtle Joel D JD Strain Misty M MM Aceves Miriam M Huang Yung-Jen YJ Reynolds Joshua A JA Hook Michelle A MA Grau James W JW
Journal of neurotrauma 20161202 6
More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery. In a clinically relevant spinal cord contusion injury model, prior work has shown that noxious stimulation at an intensity that engages pain (C) fibers soon after injury augments secondary injury and impairs functional recovery. Noxious input increases the expression of pro-inflammatory cytokines ...[more]