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Palladium(0)-catalyzed asymmetric C(sp³)-H arylation using a chiral binol-derived phosphate and an achiral ligand.

ABSTRACT: The first efficient palladium(0)-catalyzed enantioselective C(sp³)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

SUBMITTER: Yang L

PROVIDER: S-EPMC5360168 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Palladium(0)-catalyzed asymmetric C(sp3)-H arylation using a chiral binol-derived phosphate and an achiral ligand.

Yang Lei L Melot Romain R Neuburger Markus M Baudoin Olivier O

Chemical science 20161011 2

The first efficient palladium(0)-catalyzed enantioselective C(sp3)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters. ...[more]

PMID: 28451275

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