Ontology highlight
ABSTRACT:
SUBMITTER: Thomas JT
PROVIDER: S-EPMC5360445 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Thomas J Terrig JT Eric Dollins D D Andrykovich Kristin R KR Chu Tehyen T Stultz Brian G BG Hursh Deborah A DA Moos Malcolm M
eLife 20170321
The matricellular protein SMOC (Secreted Modular Calcium binding protein) is conserved phylogenetically from vertebrates to arthropods. We showed previously that SMOC inhibits bone morphogenetic protein (BMP) signaling downstream of its receptor via activation of mitogen-activated protein kinase (MAPK) signaling. In contrast, the most prominent effect of the <i>Drosophila</i> orthologue, <i>pentagone</i> (<i>pent</i>), is expanding the range of BMP signaling during wing patterning. Using SMOC de ...[more]