Ontology highlight
ABSTRACT:
SUBMITTER: Martinic MM
PROVIDER: S-EPMC5360474 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Martinic Marianne M MM Caminschi Irina I O'Keeffe Meredith M Thinnes Therese C TC Grumont Raelene R Gerondakis Steve S McKay Dianne B DB Nemazee David D Gavin Amanda L AL
Journal of immunology (Baltimore, Md. : 1950) 20170215 7
Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Although studies have addressed the role of NOD proteins in innate immune responses, little attention has been given to their impact on the developing adaptive immune system. We have assessed the roles of NOD1 and NOD2 deficiency on T cell development in mice. Our results demonstrate that NOD1 and NOD2 promote the positive selection/matur ...[more]