Ontology highlight
ABSTRACT:
SUBMITTER: Kakaradov B
PROVIDER: S-EPMC5360497 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kakaradov Boyko B Arsenio Janilyn J Widjaja Christella E CE He Zhaoren Z Aigner Stefan S Metz Patrick J PJ Yu Bingfei B Wehrens Ellen J EJ Lopez Justine J Kim Stephanie H SH Zuniga Elina I EI Goldrath Ananda W AW Chang John T JT Yeo Gene W GW
Nature immunology 20170220 4
During microbial infection, responding CD8<sup>+</sup> T lymphocytes differentiate into heterogeneous subsets that together provide immediate and durable protection. To elucidate the dynamic transcriptional changes that underlie this process, we applied a single-cell RNA-sequencing approach and analyzed individual CD8<sup>+</sup> T lymphocytes sequentially throughout the course of a viral infection in vivo. Our analyses revealed a striking transcriptional divergence among cells that had undergon ...[more]