Ontology highlight
ABSTRACT:
SUBMITTER: Deguine J
PROVIDER: S-EPMC5360520 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Deguine Jacques J Wei Jessica J Barbalat Roman R Gronert Karsten K Barton Gregory M GM
Journal of immunology (Baltimore, Md. : 1950) 20170220 7
Neutrophils are generally the first immune cells recruited during the development of sterile or microbial inflammation. As these cells express many innate immune receptors with the potential to directly recognize microbial or endogenous signals, we set out to assess whether their functions are locally influenced by the signals present at the onset of inflammation. Using a mouse model of peritonitis, we demonstrate that neutrophils elicited in the presence of C-type lectin receptor ligands have a ...[more]