Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan SR
PROVIDER: S-EPMC5362237 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Nagarajan Shilpa R SR Brandon Amanda E AE McKenna Jessie A JA Shtein Harrison C HC Nguyen Thinh Q TQ Suryana Eurwin E Poronnik Philip P Cooney Gregory J GJ Saunders Darren N DN Hoy Andrew J AJ
PloS one 20170322 3
Ubiquitin is a crucial post-translational modification regulating numerous cellular processes, but its role in metabolic disease is not well characterized. In this study, we identified the in vivo ubiquitin-modified proteome in rat liver and determined changes in this ubiquitome under acute insulin stimulation and high-fat and sucrose diet-induced insulin resistance. We identified 1267 ubiquitinated proteins in rat liver across diet and insulin-stimulated conditions, with 882 proteins common to ...[more]