Ontology highlight
ABSTRACT:
SUBMITTER: Fan W
PROVIDER: S-EPMC5362240 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Fan Wei W Lam Sin Man SM Xin Jingxue J Yang Xiao X Liu Zhonghua Z Liu Yuan Y Wang Yong Y Shui Guanghou G Huang Xun X
PLoS genetics 20170308 3
The general transcription factor TBP (TATA-box binding protein) and its associated factors (TAFs) together form the TFIID complex, which directs transcription initiation. Through RNAi and mutant analysis, we identified a specific TBP family protein, TRF2, and a set of TAFs that regulate lipid droplet (LD) size in the Drosophila larval fat body. Among the three Drosophila TBP genes, trf2, tbp and trf1, only loss of function of trf2 results in increased LD size. Moreover, TRF2 and TAF9 regulate fa ...[more]