Understanding metabolism with flux analysis: From theory to application.
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ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC5362364 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Understanding metabolism with flux analysis: From theory to application.
Dai Ziwei Z Locasale Jason W JW
Metabolic engineering 20160922 Pt B
Quantitative and qualitative knowledge of metabolic rates (i.e. fluxes) over a metabolic network and in specific cellular compartments gives insights into the regulation of metabolism and helps to understand the contribution of metabolic alterations to pathology. In this review we introduce methodology to resolve metabolic fluxes from stable isotope labeling and relevant techniques in model development, model simplification, flux uncertainty analysis and experimental design that together is term ...[more]
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