Ontology highlight
ABSTRACT:
SUBMITTER: Niu T
PROVIDER: S-EPMC5362379 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Niu Tianhua T Liu Ning N Yu Xun X Zhao Ming M Choi Hyung Jin HJ Leo Paul J PJ Brown Matthew A MA Zhang Lei L Pei Yu-Fang YF Shen Hui H He Hao H Fu Xiaoying X Lu Shan S Chen Xiang-Ding XD Tan Li-Jun LJ Yang Tie-Lin TL Guo Yan Y Cho Nam H NH Shen Jie J Guo Yan-Fang YF Nicholson Geoffrey C GC Prince Richard L RL Eisman John A JA Jones Graeme G Sambrook Philip N PN Tian Qing Q Zhu Xue-Zhen XZ Papasian Christopher J CJ Duncan Emma L EL Uitterlinden André G AG Shin Chan Soo CS Xiang Shuanglin S Deng Hong-Wen HW
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20150911 2
Protein phosphorylation regulates a wide variety of cellular processes. Thus, we hypothesize that single-nucleotide polymorphisms (SNPs) that may modulate protein phosphorylation could affect osteoporosis risk. Based on a previous conventional genome-wide association (GWA) study, we conducted a three-stage meta-analysis targeting phosphorylation-related SNPs (phosSNPs) for femoral neck (FN)-bone mineral density (BMD), total hip (HIP)-BMD, and lumbar spine (LS)-BMD phenotypes. In stage 1, 9593 ph ...[more]