Gd-TEMDO: Design, Synthesis, and MRI Application.
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ABSTRACT:
SUBMITTER: Boltjes A
PROVIDER: S-EPMC5363076 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Gd-TEMDO: Design, Synthesis, and MRI Application.
Boltjes André A Shrinidhi Annadka A van de Kolk Kees K Herdtweck Eberhardt E Dömling Alexander A
Chemistry (Weinheim an der Bergstrasse, Germany) 20160408 22
A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid-state structure, binding constant, and some MRI applications of the Gd-TEMDO complex as the first example of a congeneric family of oligo-amino tetrazoles. ...[more]
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