Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC5363296 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20170104 1
The high vulnerability of mRNA necessitates the manufacture of delivery vehicles to afford adequate protection in the biological milieu. Here, mRNA was complexed with a mixture of cRGD-poly(ethylene glycol) (PEG)-polylysine (PLys) (thiol) and poly(N-isopropylacrylamide) (PNIPAM)-PLys(thiol). The ionic complex core consisting of opposite-charged PLys and mRNA was crosslinked though redox-responsive disulfide linkage, thereby avoiding structural disassembly for exposure of mRNA to harsh biological ...[more]