Ontology highlight
ABSTRACT:
SUBMITTER: Mercey O
PROVIDER: S-EPMC5363356 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
FEBS letters 20170228 5
miR-34/449 microRNAs are conserved regulators of multiciliated cell differentiation. Here, we evidence and characterize expression of two isomiR variant sequences from the miR-34/449 family in human airway epithelial cells. These isomiRs differ from their canonical counterparts miR-34b and miR-449c by one supplemental uridine at their 5'-end, leading to a one-base shift in their seed region. Overexpression of canonical miR-34/449 or 5'-isomiR-34/449 induces distinct gene expression profiles and ...[more]