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Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment.


ABSTRACT: Cerebral microbleeds, a marker of small vessel disease, are thought to be of importance in cognitive impairment. We aimed to study topographical distribution of cerebral microbleeds, and their involvement in disease pathophysiology, reflected by cerebrospinal fluid biomarkers; 1039 patients undergoing memory investigation underwent lumbar puncture and a brain magnetic resonance imaging scan. Cerebrospinal fluid samples were analyzed for amyloid ?(A?)42, total tau(T-tau), tau phosphorylated at threonine 18(P-tau) and cerebrospinal fluid/serum albumin ratios. Magnetic resonance imaging sequences were evaluated for small vessel disease markers, including cerebral microbleeds, white matter hyperintensities and lacunes. Low A?42 levels were associated with lobar cerebral microbleeds in the whole cohort and Alzheimer's disease ( P?

SUBMITTER: Shams S 

PROVIDER: S-EPMC5363477 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment.

Shams Sara S   Granberg Tobias T   Martola Juha J   Charidimou Andreas A   Li Xiaozhen X   Shams Mana M   Fereshtehnejad Seyed-Mohammad SM   Cavallin Lena L   Aspelin Peter P   Wiberg-Kristoffersen Maria M   Wahlund Lars-Olof LO  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160721 3


Cerebral microbleeds, a marker of small vessel disease, are thought to be of importance in cognitive impairment. We aimed to study topographical distribution of cerebral microbleeds, and their involvement in disease pathophysiology, reflected by cerebrospinal fluid biomarkers; 1039 patients undergoing memory investigation underwent lumbar puncture and a brain magnetic resonance imaging scan. Cerebrospinal fluid samples were analyzed for amyloid β(Aβ)42, total tau(T-tau), tau phosphorylated at th  ...[more]

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