Dataset Information

Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.

ABSTRACT:

Objective

We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population.

Methods

In a case-control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in RTEL1 were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender.

Results

In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10-0.82; P=0.02). In the genetic model analysis, we found that the "C/C" genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13-0.86; P=0.022) and recessive model (OR =0.32; 95% CI =0.12-0.80; P=0.009).

Conclusion

Our data shed new light on the association between genetic polymorphisms of RTEL1 and COPD susceptibility in the Chinese Han population.

SUBMITTER: Ding Y

PROVIDER: S-EPMC5364006 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Association between <i>RTEL1</i> gene polymorphisms and COPD susceptibility in a Chinese Han population.

Ding Yipeng Y Xu Heping H Yao Jinjian J Xu Dongchuan D He Ping P Yi Shengyang S Li Quanni Q Liu Yuanshui Y Wu Cibing C Tian Zhongjie Z

International journal of chronic obstructive pulmonary disease 20170317

<h4>Objective</h4>We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (<i>RTEL1</i>), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population.<h4>Methods</h4>In a case-control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms in <i>RTEL1</i> were select ...[more]

PMID: 28360516

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