Ontology highlight
ABSTRACT:
SUBMITTER: Tesini BL
PROVIDER: S-EPMC5364303 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Tesini Brenda L BL Wright Terry W TW Malone Jane E JE Haidaris Constantine G CG Harber Martha M Sant Andrea J AJ Nayak Jennifer L JL Gigliotti Francis F
Infection and immunity 20170323 4
<i>Pneumocystis</i> pneumonia (PcP) is a life-threatening infection that affects immunocompromised individuals. Nearly half of all PcP cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. To this end, we have identified a unique mouse <i>Pneumocystis</i> surface protein, designated <i>Pneumocystis</i> cross-reactive antigen 1 (Pca1), as a potential vaccine candidate. Mice were immunized with a recombinant fusion protein containing ...[more]