Ontology highlight
ABSTRACT:
SUBMITTER: Barr AR
PROVIDER: S-EPMC5364389 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Barr Alexis R AR Cooper Samuel S Heldt Frank S FS Butera Francesca F Stoy Henriette H Mansfeld Jörg J Novák Béla B Bakal Chris C
Nature communications 20170320
Following DNA damage caused by exogenous sources, such as ionizing radiation, the tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. However, the role of p21 in maintaining genomic stability in the absence of exogenous DNA-damaging agents is unclear. Here, using live single-cell measurements of p21 protein in proliferating cultures, we show that naturally occurring DNA damage incurred over S-phase causes p53-dependent accumulation of p21 during mother G2- ...[more]