Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5364507 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zhang Yushuo Y Chen Fei F Tai Guomei G Wang Jiaojiao J Shang Jun J Zhang Bing B Wang Ping P Huang Baoxing B Du Jie J Yu Jiahua J Zhang Haowen H Liu Fenju F
Scientific reports 20170324
The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize ...[more]