Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC5609961 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Oncotarget 20170708 38
CLC-3 chloride channel plays important roles on cell volume regulation, proliferation and migration in normal and cancer cells. Recent growing evidence supports a critical role of CLC-3 in glioma metastasis, however, the mechanism underlying is unclear. This study finds that CLC-3 is upregulated in glioma tissues and positively correlated with WHO histological grade. Patients with high CLC-3 expression had an overall shorter survival time, whereas patients with low expression of CLC-3 had a bett ...[more]