Ontology highlight
ABSTRACT:
SUBMITTER: Pillow TH
PROVIDER: S-EPMC5365059 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Pillow Thomas H TH Sadowsky Jack D JD Zhang Donglu D Yu Shang-Fan SF Del Rosario Geoffrey G Xu Keyang K He Jintang J Bhakta Sunil S Ohri Rachana R Kozak Katherine R KR Ha Edward E Junutula Jagath R JR Flygare John A JA
Chemical science 20160822 1
Disulfide bonds provide a bioactivatable connection with applications in imaging and therapy. The circulation stability and intracellular release of disulfides are problematically coupled in that increasing stability causes a corresponding decrease in cleavage and payload release. However, an antibody offers the potential for a reversible stabilization. We examined this by attaching a small molecule directly to engineered cysteines in an antibody. At certain sites this unhindered disulfide was s ...[more]