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Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

ABSTRACT: Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

SUBMITTER: Gangar A 

PROVIDER: S-EPMC3312035 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers.

Gangar Amit A   Fegan Adrian A   Kumarapperuma Sidath C SC   Wagner Carston R CR  

Journal of the American Chemical Society 20120201 6

Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate. ...[more]

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