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Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.

ABSTRACT: We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

SUBMITTER: Adams Waldorf KM 

PROVIDER: S-EPMC5365281 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.

Adams Waldorf Kristina M KM   Stencel-Baerenwald Jennifer E JE   Kapur Raj P RP   Studholme Colin C   Boldenow Erica E   Vornhagen Jay J   Baldessari Audrey A   Dighe Manjiri K MK   Thiel Jeff J   Merillat Sean S   Armistead Blair B   Tisoncik-Go Jennifer J   Green Richard R RR   Davis Michael A MA   Dewey Elyse C EC   Fairgrieve Marian R MR   Gatenby J Christopher JC   Richards Todd T   Garden Gwenn A GA   Diamond Michael S MS   Juul Sandra E SE   Grant Richard F RF   Kuller LaRene L   Shaw Dennis W W DW   Ogle Jason J   Gough G Michael GM   Lee Wonsok W   English Chris C   Hevner Robert F RF   Dobyns William B WB   Gale Michael M   Rajagopal Lakshmi L  

Nature medicine 20160912 11

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic eval  ...[more]

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