Ontology highlight
ABSTRACT:
SUBMITTER: Adams Waldorf KM
PROVIDER: S-EPMC5365281 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Adams Waldorf Kristina M KM Stencel-Baerenwald Jennifer E JE Kapur Raj P RP Studholme Colin C Boldenow Erica E Vornhagen Jay J Baldessari Audrey A Dighe Manjiri K MK Thiel Jeff J Merillat Sean S Armistead Blair B Tisoncik-Go Jennifer J Green Richard R RR Davis Michael A MA Dewey Elyse C EC Fairgrieve Marian R MR Gatenby J Christopher JC Richards Todd T Garden Gwenn A GA Diamond Michael S MS Juul Sandra E SE Grant Richard F RF Kuller LaRene L Shaw Dennis W W DW Ogle Jason J Gough G Michael GM Lee Wonsok W English Chris C Hevner Robert F RF Dobyns William B WB Gale Michael M Rajagopal Lakshmi L
Nature medicine 20160912 11
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic eval ...[more]